Lane 1: 293T
Lane 2: A431
Lane 3: Hela
Recombinant Rabbit monoclonal primary
14-3-3 gamma Recombinant Rabbit Monoclonal Antibody [SD20-65] (ET1612-9)
A431, Hela, 293T.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
14 3 3 gamma antibody; 14 3 3 protein gamma antibody; 14 3 3 protein gamma subtype antibody; 14 3 3gamma antibody; 14-3-3 protein gamma antibody; 1433G_HUMAN antibody; 3 monooxygenase/tryptophan 5 monooxgenase activation protein gamma polypeptide antibody; KCIP 1 antibody; KCIP-1 antibody; KCIP1 antibody; N-terminally processed antibody; Protein kinase C inhibitor protein 1 antibody; Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein gamma polypeptide antibody; Ywhag antibody
Belongs to the 14-3-3 family.
Highly expressed in brain, skeletal muscle, and heart.
Phosphorylated by various PKC isozymes.
14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 b, g, e, z, h, q and s. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins; by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity, and facilitation of protein modification. Loss of expression contributes to a vast array of pathogenic cellular activities.