14-3-3 alpha+beta Mouse Monoclonal Antibody [9-26] (M0407-14)

UNIPROT #

P31946

PROTEIN NAME

14-3-3 alpha+beta

SYNONYMS

14 3 3 alpha antibody;14 3 3 protein beta/alpha antibody;14-3-3 protein beta/alpha antibody;1433B_HUMAN antibody;Brain protein 14 3 3 beta isoform antibody;GW128 antibody;HS 1 antibody;KCIP-1 antibody;KCIP1 antibody;N-terminally processed antibody;Protein 1054 antibody;Protein kinase C inhibitor protein 1 antibody;YWHAA antibody;YWHAB antibody

SEQUENCE SIMILARITIES

Belongs to the 14-3-3 family.

POST-TRANSLATIONAL MODIFICATION

The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.

SUBCELLULAR LOCATION

Cytoplasm, Membrane, Vacuole.

FUNCTION

The 14-3-3 proteins are a family of proteins involved in the regulation of apoptosis, mitogenic signaling and cell-cycle checkpoints. The 14-3-3 proteins are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. Through binding Bad, 14-3-3 prevents apoptosis by sequestering Bad to the cytosol. The 14-3-3 proteins are also Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. They bind to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.