Frizzled-5 Rabbit Polyclonal Antibody (0905-3)

UNIPROT #

Q13467

PROTEIN NAME

Frizzled-5

SYNONYMS

C2orf31 antibody;DKFZP434E2135 antibody;Frizzled 5 seven transmembrane spanning receptor antibody;Frizzled class receptor 5 antibody;Frizzled family receptor 5 antibody;Frizzled homolog 5 antibody;Frizzled-5 antibody;Frizzled5 antibody;Fz 5 antibody;Fz-5 antibody;Fz5 antibody;FZD 5 antibody;fzd5 antibody;FZD5_HUMAN antibody;FzE 5 antibody;FzE5 antibody;HFZ 5 antibody;hFz5 antibody;MGC129692 antibody;Seven transmembrane receptor frizzled 5 antibody;Uncharacterized protein C2orf31 antibody;Wnt receptor antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor Fz/Smo family.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome.

SUBCELLULAR LOCATION

Cell membrane.Golgi apparatus. Membrane. Synapse.

FUNCTION

Frizzled-5 belongs to the G-protein coupled receptor Fz/Smo family, contains 585 amino acids. It is localized at the plasma membrane and also found at the Golgi. Fzds have a large extracellular N-terminal region containing a cysteine-rich domain (CRD), which is involved in binding to Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.