Lane 1: Mouse heart
Lane 2: Mouse skeletal muscle
Recombinant Rabbit monoclonal primary
Caveolin-3 Recombinant Rabbit Monoclonal Antibody [SY22-06] (ET1607-16)
Recombinant protein within human caveolin-3 aa 1-125 / 151.
Mouse heart tissue, mouse skeletal muscle tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
CAV3 antibody; CAV3_HUMAN antibody; Caveolin 3 antibody; Caveolin-3 antibody; LGMD1C antibody; LQT9 antibody; M-caveolin antibody; MGC126100 antibody; MGC126101 antibody; MGC126129 antibody; OTTHUMP00000115603 antibody; OTTHUMP00000207105 antibody; VIP 21 antibody; VIP21 antibody
Belongs to the caveolin family.
Expressed predominantly in muscle.
Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2.
Golgi apparatus membrane, Cell membrane, Membrane.
Caveolae (also known as plasmalemmal vesicles) are 50-100 nM flask-shaped membranes that represent a subcompartment of the plasma membrane. On the basis of morphological studies, caveolae have been implicated to function in the transcytosis of various macromolecules (including LDL) across capillary endothelial cells, uptake of small molecules via potocytosis and the compartmentalization of certain signaling molecules including G protein-coupled receptors. Three proteins, caveolin-1, caveolin-2 and caveolin-3, have been identified as principal components of caveolae. Two forms of caveolin-1, designated alpha and beta, share a distinct but overlapping cellular distribution and differ by an amino terminal 31 amino acid sequence which is absent from the beta isoform. Caveolin-1 shares 31% identity with caveolin-2 and 65% identity with caveolin-3 at the amino acid level. Functionally, the three proteins differ in their interactions with heterotrimeric G protein isoforms.