PRODUCT CODE: ET1607-16

Caveolin-3 Recombinant Rabbit Monoclonal Antibody [SY22-06] (ET1607-16)

  • Recombinant

Applications

  • WB

  • IP

REACTIVITY

  • Human

  • Mouse

  • Rat

Western blot analysis of Caveolin-3 on different lysates using anti-Caveolin-3 antibody at 1/1,000 dilution.<br />
Positive control:   <br />
Lane 1: Mouse heart      <br />
Lane 2: Mouse skeletal muscle
  • Western blot analysis of Caveolin-3 on different lysates using anti-Caveolin-3 antibody at 1/1,000 dilution.<br />
Positive control:   <br />
Lane 1: Mouse heart      <br />
Lane 2: Mouse skeletal muscle
Western blot analysis of Caveolin-3 on different lysates using anti-Caveolin-3 antibody at 1/1,000 dilution.
Positive control:
Lane 1: Mouse heart
Lane 2: Mouse skeletal muscle

Applications

  • WB

  • IP

REACTIVITY

  • Human

  • Mouse

  • Rat

SPECIFICATIONS

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Caveolin-3 Recombinant Rabbit Monoclonal Antibody [SY22-06] (ET1607-16)

Immunogen

Recombinant protein within human caveolin-3 aa 1-125 / 151.

Host

Rabbit

Positive Control

Mouse heart tissue, mouse skeletal muscle tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SY22-06

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein A purified.

MOLECULAR WEIGHT

17 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:1,000-1:5,000

TARGET

UNIPROT #

PROTEIN NAME

Caveolin-3

SYNONYMS

CAV3 antibody; CAV3_HUMAN antibody; Caveolin 3 antibody; Caveolin-3 antibody; LGMD1C antibody; LQT9 antibody; M-caveolin antibody; MGC126100 antibody; MGC126101 antibody; MGC126129 antibody; OTTHUMP00000115603 antibody; OTTHUMP00000207105 antibody; VIP 21 antibody; VIP21 antibody

SEQUENCE SIMILARITIES

Belongs to the caveolin family.

TISSUE SPECIFICITY

Expressed predominantly in muscle.

POST-TRANSLATIONAL MODIFICATION

Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2.

SUBCELLULAR LOCATION

Golgi apparatus membrane, Cell membrane, Membrane.

FUNCTION

Caveolae (also known as plasmalemmal vesicles) are 50-100 nM flask-shaped membranes that represent a subcompartment of the plasma membrane. On the basis of morphological studies, caveolae have been implicated to function in the transcytosis of various macromolecules (including LDL) across capillary endothelial cells, uptake of small molecules via potocytosis and the compartmentalization of certain signaling molecules including G protein-coupled receptors. Three proteins, caveolin-1, caveolin-2 and caveolin-3, have been identified as principal components of caveolae. Two forms of caveolin-1, designated alpha and beta, share a distinct but overlapping cellular distribution and differ by an amino terminal 31 amino acid sequence which is absent from the beta isoform. Caveolin-1 shares 31% identity with caveolin-2 and 65% identity with caveolin-3 at the amino acid level. Functionally, the three proteins differ in their interactions with heterotrimeric G protein isoforms.