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VEGF Recombinant Rabbit Monoclonal Antibody [SP07-01] (ET1604-28)

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Catalog# ET1604-28

Rabbit Monoclonal to VEGF

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IHC-P

  • IP

  • FC

React with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
This product has been cited in peer reviewed publications, see list HERE

Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

VEGF Recombinant Rabbit Monoclonal Antibody [SP07-01] (ET1604-28)

Immunogen

Synthetic peptide within human vegf aa 183-232 / 232.

Host

Rabbit

Positive Control

Hela cell lysate, A431 cell lysate, Hela, MCF-7, SHG-44, SH-SY5Y, human colon carcinoma tissue, human breast carcinoma tissue, human kidney tissue, mouse kidney tissue, mouse cerebellum tissue,mouse hippocampus tissue ,mouse brain tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SP07-01

APPLICATION DILUTION

  • WB:1:500-1:2,000

  • IF-Cell

  • 1:50-1:200

  • IF-Tissue

  • 1:50-1:200

  • IHC-P:1:50-1:200

  • FC

  • 1:50-1:100

  • IP

  • Use at an assay dependent concentration.

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

27 kDa

Isotype

IgG

TARGET

UNIPROT #

P15692

PROTEIN NAME

VEGF

SYNONYMS

Folliculostellate cell-derived growth factor antibody;Glioma-derived endothelial cell mitogen antibody;MGC70609 antibody;MVCD1 antibody;Vascular endothelial growth factor A antibody;vascular endothelial growth factor A121 antibody;vascular endothelial growth factor A165 antibody;vascular endothelial growth factor antibody;Vascular permeability factor antibody;VEGF A antibody;Vegf antibody;VEGF-A antibody;VEGF120 antibody;Vegfa antibody;VEGFA_HUMAN antibody;VPF antibody

SEQUENCE SIMILARITIES

Belongs to the PDGF/VEGF growth factor family.

TISSUE SPECIFICITY

Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include fibroblast growth factors (FGFs), platelet derived growth factor (PDGF) and vascular endothelial growth factor (VEGF). VEGF is a dimeric glycoprotein with structural homology to PDGF. Several variants of VEGF have been described that arise by alternative mRNA splicing. It has been speculated that VEGF may function as a tumor angiogenesis factor in vivo because the expression pattern of VEGF is consistent with a role in embryonic angiogenesis. VEGF mRNA is formed in some primary tumors, VEGF is produced by tumor cell lines in vitro and VEGF mitogenic activity appears to be restricted to endothelial cells. A member of the PDGF receptor family, Flt, has been identified as a high-affinity receptor for VEGF.

CITATIONS

  • Chen, Xin et al.

    SOX5 induces lung adenocarcinoma angiogenesis by inducing the expression of VEGF through STAT3 signaling. | OncoTargets and Therapy [2018]

  • Luo, C., Zhou, M., Chen, C., Li, S., Li, Q., Huang, Y., & Zhou, Z.

    A liposome-based combination strategy using doxorubicin and a PI3K inhibitor efficiently inhibits pre-metastatic initiation by acting on both tumor cells and tumor-associated macrophages

  • Li, Y., Cai, W., Jin, F., Wang, X., Liu, W., Li, T., Yang, X., Liu, H., Xu, H., & Yang, F.

    Thalidomide Alleviates Pulmonary Fibrosis Induced by Silica in Mice by Inhibiting ER Stress and the TLR4-NF-κB Pathway

  • Liu, Y., Chen, Y., Wang, Y., Jiang, S., Lin, W., Wu, Y., Li, Q., Guo, Y., Liu, W., & Yuan, Q.

    DNA demethylase ALKBH1 promotes adipogenic differentiation via regulation of HIF-1 signaling

  • Li, S., Li, L., Lin, X., Chen, C., Luo, C., & Huang, Y.

    Targeted Inhibition of Tumor Inflammation and Tumor-Platelet Crosstalk by Nanoparticle-Mediated Drug Delivery Mitigates Cancer Metastasis

  • Zhang, C., Xie, Y., Lai, R., Wu, J., & Guo, Z.

    Nonsynonymous C1653T Mutation of Hepatitis B Virus X Gene Enhances Malignancy of Hepatocellular Carcinoma Cells

  • Chen, Y., Lu, Z., Qi, C., Yu, C., Li, Y., Huan, W., Wang, R., Luo, W., Shen, D., Ding, L., Ren, L., Xie, H., Xue, D., Wang, M., Ni, K., Xia, L., Qian, J., & Li, G.

    N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma

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