Lane 1: Hela cell lysate
Lane 2: A431 cell lysate
Recombinant Rabbit monoclonal primary
VEGF Recombinant Rabbit Monoclonal Antibody [SP07-01] (ET1604-28)
Synthetic peptide within human vegf aa 183-232 / 232.
Hela cell lysate, A431 cell lysate, Hela, MCF-7, SHG-44, SH-SY5Y, human colon carcinoma tissue, human breast carcinoma tissue, human kidney tissue, mouse kidney tissue, mouse cerebellum tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Folliculostellate cell-derived growth factor antibody; Glioma-derived endothelial cell mitogen antibody; MGC70609 antibody; MVCD1 antibody; Vascular endothelial growth factor A antibody; vascular endothelial growth factor A121 antibody; vascular endothelial growth factor A165 antibody; vascular endothelial growth factor antibody; Vascular permeability factor antibody; VEGF A antibody; Vegf antibody; VEGF-A antibody; VEGF120 antibody; Vegfa antibody; VEGFA_HUMAN antibody; VPF antibody
Belongs to the PDGF/VEGF growth factor family.
Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland.
The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include fibroblast growth factors (FGFs), platelet derived growth factor (PDGF) and vascular endothelial growth factor (VEGF). VEGF is a dimeric glycoprotein with structural homology to PDGF. Several variants of VEGF have been described that arise by alternative mRNA splicing. It has been speculated that VEGF may function as a tumor angiogenesis factor in vivo because the expression pattern of VEGF is consistent with a role in embryonic angiogenesis. VEGF mRNA is formed in some primary tumors, VEGF is produced by tumor cell lines in vitro and VEGF mitogenic activity appears to be restricted to endothelial cells. A member of the PDGF receptor family, Flt, has been identified as a high-affinity receptor for VEGF.
Chen, Xin et al.
SOX5 induces lung adenocarcinoma angiogenesis by inducing the expression of VEGF through STAT3 signaling. | OncoTargets and Therapy