Lane 1: Hela cell lysate
Lane 2: Human liver tissue lysate
Recombinant Rabbit monoclonal primary
TXNRD1 Recombinant Rabbit Monoclonal Antibody [JA11-32] (ET1704-81)
Human liver tissue lysate, Hela, HUVEC, SH-SY5Y, mouse testes tissue, human kidney tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
cytoplasmic antibody; Gene associated with retinoic and IFN-induced mortality 12 protein antibody; Gene associated with retinoic and interferon-induced mortality 12 protein antibody; Gene associated with retinoid IFN induced mortality 12 protein antibody; GRIM 12 antibody; GRIM-12 antibody; GRIM12 antibody; KDRF antibody; KM 102 derived reductase like factor antibody; KM-102-derived reductase-like factor antibody; MGC9145 antibody; Oxidoreductase antibody; Thioredoxin reductase 1 antibody; Thioredoxin reductase 1 cytoplasmic antibody; Thioredoxin reductase GRIM 12 antibody; Thioredoxin reductase TR1 antibody; TR 1 antibody; TR antibody; TR1 antibody; TRXR 1 antibody; TRXR1 antibody; TRXR1_HUMAN antibody; TXNR antibody; TXNRD 1 antibody; Txnrd1 antibody
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver.
The N-terminus of isoform 5 is blocked.; ISGylated.
Thioredoxin (Trx) is a redox protein that is found in several species, such as bacteria, plants and mammals, and contains a conserved active site, consisting of Trp-Cys-Gly-Pro-Cys. Trx reductases (TrxR1 and TrxR2) are ubiquitous Ly noble flavoproteins that catalyze the NADPH-dependent reduction of Trx as well as several other oxidized cellular components. Mammalian Trx reductases are a part of a selenium-containing pyridine nucleotide-disulphide oxidoreductase family, which has a conserved catalytic site of Cys-Val- Asn-Val-Gly-Cys. TrxR1 and TrxR2 are also involved in the prevention of oxidative stress. Inhibition of TrxR activity may provide for potential treatments of cancer, AIDS and other autoimmune diseases as well as bacterial infections and parasitic diseases.
Yu, Jia-Tian et al.
Up-regulation of antioxidative proteins TRX1, TXNL1 and TXNRD1 in the cortex of PTZ kindling seizure model mice. | PloS One