Syntrophin alpha 1 Rabbit Polyclonal Antibody (ER1901-40)

UNIPROT #

Q13424

PROTEIN NAME

Syntrophin alpha 1

SYNONYMS

59 kDa dystrophin-associated protein A1 acidic component 1 antibody;Alpha-1-syntrophin antibody;Pro-TGF-alpha cytoplasmic domain-interacting protein 1 antibody;SNT1 antibody;SNT2 antibody;SNT3 antibody;Snta1 antibody;SNTA1_HUMAN antibody;SNTB1 antibody;SNTB2 antibody;Syntrophin alpha 1 antibody;Syntrophin beta 1 antibody;Syntrophin beta 2 antibody;Syntrophin-1 antibody;TACIP1 antibody

SEQUENCE SIMILARITIES

Belongs to the syntrophin family.

TISSUE SPECIFICITY

High expression in skeletal muscle and heart. Low expression in brain, pancreas, liver, kidney and lung. Not detected in placenta.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD (By similarity).

SUBCELLULAR LOCATION

Sarcolemma, cytoskeleton, cell junction.

FUNCTION

Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue.