Positive control:
Lane 1: Mouse skeletal muscle tissue lysate
Lane 2: Rat skeletal muscle tissue lysate
Applications
-
WB
-
ICC
-
FC
REACTIVITY
-
Human
-
Mouse
-
Rat
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
Syntrophin alpha 1 Rabbit Polyclonal Antibody (ER1901-40)
Immunogen
Synthetic peptide within mouse syntrophin alpha 1 aa 174-223 / 503.
Host
Rabbit
Positive Control
Mouse skeletal muscle tissue lysate, rat skeletal muscle tissue lysate, SW620, SiHa.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Peptide affinity purified.
MOLECULAR WEIGHT
54 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB:1:500-1:2,000
-
ICC:1:50-1:100
-
FC:1:50-1:100
TARGET
UNIPROT #
PROTEIN NAME
Syntrophin alpha 1
SYNONYMS
59 kDa dystrophin-associated protein A1 acidic component 1 antibody; Alpha-1-syntrophin antibody; Pro-TGF-alpha cytoplasmic domain-interacting protein 1 antibody; SNT1 antibody; SNT2 antibody; SNT3 antibody; Snta1 antibody; SNTA1_HUMAN antibody; SNTB1 antibody; SNTB2 antibody; Syntrophin alpha 1 antibody; Syntrophin beta 1 antibody; Syntrophin beta 2 antibody; Syntrophin-1 antibody; TACIP1 antibody
SEQUENCE SIMILARITIES
Belongs to the syntrophin family.
TISSUE SPECIFICITY
High expression in skeletal muscle and heart. Low expression in brain, pancreas, liver, kidney and lung. Not detected in placenta.
POST-TRANSLATIONAL MODIFICATION
Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD (By similarity).
SUBCELLULAR LOCATION
Sarcolemma, cytoskeleton, cell junction.
FUNCTION
Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue.