SOX9 Recombinant Rabbit Monoclonal Antibody [SN74-09] (ET1611-56)

UNIPROT #

P48436

PROTEIN NAME

SOX9

SYNONYMS

campomelic dysplasia autosomal sex reversal antibody;CMD 1 antibody;CMD1 antibody;CMPD 1 antibody;CMPD1 antibody;SOX 9 antibody;Sox9 antibody;SOX9_HUMAN antibody;SRA 1 antibody;SRA1 antibody;SRXX2 antibody;SRXY10 antibody;SRY (sex determining region Y) box 9 (campomelic dysplasia autosomal antibody;SRY (sex determining region Y) box 9 antibody;SRY (sex determining region Y)-box 9 antibody;SRY (sex-determining region Y)-box 9 protein antibody;SRY related HMG box gene 9 antibody;Transcription factor SOX 9 antibody;Transcription factor SOX-9 antibody;transcription factor SOX9 antibody

POST-TRANSLATIONAL MODIFICATION

Acetylated; acetylation impairs nuclear localization and ability to transactivate expression of target genes. Deacetylated by SIRT1.; Phosphorylation at Ser-64 and Ser-211 by PKA increases transcriptional activity and may help delay chondrocyte maturation downstream of PTHLH/PTHrP signaling. Phosphorylation at either Ser-64 or Ser-211 is required for sumoylation, but phosphorylation is not dependent on sumoylation. Phosphorylated on tyrosine residues; tyrosine dephosphorylation by PTPN11/SHP2 blocks SOX9 phosphorylation by PKA and subsequent SUMOylation.; Ubiquitinated; ubiquitination leads to proteasomal degradation and is negatively regulated by DDRGK1.; Sumoylated; phosphorylation at either Ser-64 or Ser-211 is required for sumoylation. Sumoylation is induced by BMP signaling pathway.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

SOX-9 recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It is expressed by proliferating but not hypertrophic chondrocytes that is essential for differentiation of precursor cells into chondrocytes and, with steroidogenic factor 1, regulates transcription of the anti-Müllerian hormone (AMH) gene. SOX-9 also plays a pivotal role in male sexual development; by working with Sf1, SOX-9 can produce AMH in Sertoli cells to inhibit the creation of a female reproductive system. It also interacts with a few other genes to promote the development of male sexual organs. The process starts when the transcription factor Testis determining factor (encoded by the sex-determining region SRY of the Y chromosome) activates SOX-9 activity by binding to an enhancer sequence upstream of the gene. Next, Sox9 activates FGF9 and forms feedforward loops with FGF9[ and PGD2. These loops are important for producing SOX-9; without these loops, SOX-9 would run out and the development of a female would almost certainly ensue. Activation of FGF9 by SOX-9 starts vital processes in male development, such as the creation of testis cords and the multiplication of Sertoli cells.