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RYR2 Rabbit Polyclonal Antibody (ER1803-22)

Price: Regular price $295.00

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Catalog# ER1803-22

Rabbit Polyclonal to RYR2

Tested for

  • WB

  • ICC

  • IHC-P

  • FC

React with

  • Human

  • Mouse

  • Rat

Specifications

Product Type

Rabbit polyclonal primary

Product Name

RYR2 Rabbit Polyclonal Antibody (ER1803-22)

Immunogen

Synthetic peptide within human ryr2 aa 1,471-1,520 / 4,967.

Host

Rabbit

Positive Control

293T, LOVO, SH-SY-5Y, human fetal skeletal muscle tissue, mouse brain tissue, mouse cerebellum tissue, rat skeletal muscle tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

APPLICATION DILUTION

  • WB

  • 1:500

  • ICC

  • 1:50-1:100

  • IHC-P

  • 1:50-1:200

  • FC

  • 1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

565 kDa

Isotype

IgG

TARGET

UNIPROT #

Q92736

PROTEIN NAME

RYR2

SYNONYMS

Arrhythmogenic right ventricular dysplasia 2 antibody;ARVC2 antibody;ARVD2 antibody;Brain ryanodine receptor calcium release channel antibody;Brain type ryanodine receptor antibody;Cardiac muscle ryanodine receptor calcium release channel antibody;Cardiac muscle type ryanodine receptor antibody;CCO antibody;Central core disease of muscle antibody;HBRR antibody;hRYR 2 antibody;hRYR2 antibody;MHS antibody;MHS1 antibody;Ryanodine receptor 1 (skeletal) antibody;Ryanodine receptor 1 antibody;Ryanodine receptor 2 (cardiac) antibody;Ryanodine receptor 2 antibody;Ryanodine receptor 3 antibody;Ryanodine receptor type1 antibody;RYDR antibody;RYR 1 antibody;RYR 2 antibody;RYR 3 antibody;RYR antibody;RYR-1 antibody;RyR1 antibody;RYR1_HUMAN antibody;RYR2 antibody;RYR3 antibody;Sarcoplasmic reticulum calcium release channel antibody;Skeletal muscle calcium release channel antibody;Skeletal muscle ryanodine receptor antibody;Skeletal muscle type ryanodine receptor antibody;Skeletal muscle-type ryanodine receptor antibody;SKRR antibody;Type 1 like ryanodine receptor antibody;Type 1 ryanodine receptor antibody;VTSIP antibody

SEQUENCE SIMILARITIES

Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR2 subfamily.

TISSUE SPECIFICITY

Detected in heart muscle (at protein level). Heart muscle, brain (cerebellum and hippocampus) and placenta.

DEVELOPMENTAL STAGE

Expressed in myometrium during pregnancy.

POST-TRANSLATIONAL MODIFICATION

Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2808 and Ser-2814 increases the open probability of the calcium channel. Phosphorylation is increased in failing heart, leading to calcium leaks and increased cytoplasmic Ca(2+) levels.; Phosphorylation at Ser-2031 by PKA enhances the response to lumenal calcium.

SUBCELLULAR LOCATION

Membrane. Sarcoplasmic reticulum.

FUNCTION

Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca2+ levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.

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