Ryanodine receptor 2 / RYR-2 Rabbit Polyclonal Antibody (ER1803-22)

UNIPROT #

Q92736

PROTEIN NAME

RYR2

SYNONYMS

Arrhythmogenic right ventricular dysplasia 2 antibody;ARVC2 antibody;ARVD2 antibody;Brain ryanodine receptor calcium release channel antibody;Brain type ryanodine receptor antibody;Cardiac muscle ryanodine receptor calcium release channel antibody;Cardiac muscle type ryanodine receptor antibody;CCO antibody;Central core disease of muscle antibody;HBRR antibody;hRYR 2 antibody;hRYR2 antibody;MHS antibody;MHS1 antibody;Ryanodine receptor 1 (skeletal) antibody;Ryanodine receptor 1 antibody;Ryanodine receptor 2 (cardiac) antibody;Ryanodine receptor 2 antibody;Ryanodine receptor 3 antibody;Ryanodine receptor type1 antibody;RYDR antibody;RYR 1 antibody;RYR 2 antibody;RYR 3 antibody;RYR antibody;RYR-1 antibody;RyR1 antibody;RYR1_HUMAN antibody;RYR2 antibody;RYR3 antibody;Sarcoplasmic reticulum calcium release channel antibody;Skeletal muscle calcium release channel antibody;Skeletal muscle ryanodine receptor antibody;Skeletal muscle type ryanodine receptor antibody;Skeletal muscle-type ryanodine receptor antibody;SKRR antibody;Type 1 like ryanodine receptor antibody;Type 1 ryanodine receptor antibody;VTSIP antibody

SEQUENCE SIMILARITIES

Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR2 subfamily.

TISSUE SPECIFICITY

Detected in heart muscle (at protein level). Heart muscle, brain (cerebellum and hippocampus) and placenta.

DEVELOPMENTAL STAGE

Expressed in myometrium during pregnancy.

POST-TRANSLATIONAL MODIFICATION

Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2808 and Ser-2814 increases the open probability of the calcium channel. Phosphorylation is increased in failing heart, leading to calcium leaks and increased cytoplasmic Ca(2+) levels.; Phosphorylation at Ser-2031 by PKA enhances the response to lumenal calcium.

SUBCELLULAR LOCATION

Membrane. Sarcoplasmic reticulum.

FUNCTION

Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca2+ levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.