RYBP Rabbit Polyclonal Antibody (HA500348)

UNIPROT #

Q8N488

PROTEIN NAME

RYBP

SYNONYMS

2410018J24Rik antibody;AAP 1 antibody;AAP1 antibody;APAP 1 antibody;APAP-1 antibody;APAP1 antibody;Apoptin associating protein 1 antibody;Apoptin-associating protein 1 antibody;cb337 antibody;Death effector domain associated factor antibody;Death effector domain-associated factor antibody;Death effector domain-associated factor B antibody;DED associated factor antibody;DED-associated factor antibody;DED-associated factor B antibody;DEDAF antibody;MGC62213 antibody;RING1 and YY1 binding protein a antibody;RING1 and YY1 binding protein antibody;RING1 and YY1-binding protein antibody;RING1 and YY1-binding protein B antibody;Ring1 interactor RYBP antibody;RYBP antibody;RYBP_HUMAN antibody;rybpa antibody;wu:fi34f03 antibody;YEAF 1 antibody;YEAF1 antibody;YY1 and E4TF1 associated factor 1 antibody;YY1 and E4TF1-associated factor 1 antibody;YY1- and E4TF1/GABP-associated factor 1 antibody;zgc:153842 antibody

SUBCELLULAR LOCATION

Cytoplasm, nucleus, nucleoplasm.

FUNCTION

The products of the Polycomb group (PcG) of genes are necessary for the maintenance of transcriptional repression of a number of important developmental genes, including the homeotic genes. RYBP is a member of the mammalian polycomb complex. RYBP (RING1- and YY1-binding protein) interacts specifically with the E2F2 and E2F3 family members, dependent on the marked box domain in these proteins. YY1 and RYBP, in combination with either E2F2 or E2F3, can stimulate Cdc6 promoter activity synergistically, at G1/S of the cell cycle. RYBP also complexes with both RING1 proteins (RING1 and RING1B) and with M33, two mutually interacting sets of proteins of the mammalian Polycomb complex. RING1 binds RYBP and M33 through the same C-terminal domain, whereas the RYBP-M33 interaction takes place through an M33 domain not involved in binding.