RAB5C Recombinant Rabbit Monoclonal Antibody [JE63-14] (HA721012)

UNIPROT #

P51148

PROTEIN NAME

RAB5C

SYNONYMS

L1880 antibody;RAB, member of RAS oncogene family like antibody;RAB5C antibody;RAB5C, member of RAS oncogene family antibody;RAB5C, member RAS oncogene family antibody;RAB5C_HUMAN antibody;RAB5CL antibody;RAB5L antibody;RABL antibody;Ras-related protein Rab-5C antibody

SUBCELLULAR LOCATION

Early endosome membrane, Cell membrane, Melanosome.

FUNCTION

The Ras-related superfamily of guanine nucleotide binding proteins, which includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies, exhibit 30-60% homology with Ras p21. Accumulating data suggests an important role for Rab proteins, either in endocytosis or in biosynthetic protein transport. The transport of newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves at each stage the movement of carrier vesicles, a process that appears to involve Rab protein function. The possibility that Rab proteins might also direct the exocytosis from secretory vesicles to the plasma membrane is supported by the observation that in yeast, the SEC4 protein, which is 40% homologous to Rab proteins, is associated with secretory vesicles. At least eight members of the Rab subfamily have been identified, each of which is found at a particular stage of a membrane transport pathway.