Phospho-RSK1 p90 (T359+S363) Recombinant Rabbit Monoclonal Antibody [SU03-65] (ET1608-53)

UNIPROT #

Q15418

PROTEIN NAME

Phospho-RSK1 p90 (T359+S363)

SYNONYMS

90 kDa ribosomal protein S6 kinase 1 antibody;dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1 antibody;dJ590P13.1 antibody;EC 2.7.11.1 antibody;HU 1 antibody;HU1 antibody;KS6A1_HUMAN antibody;MAP kinase activated protein kinase 1a antibody;MAP kinase-activated protein kinase 1a antibody;MAPK-activated protein kinase 1a antibody;MAPKAP kinase 1a antibody;MAPKAPK-1a antibody;MAPKAPK1A antibody;MGC79981 antibody;Mitogen-activated protein kinase-activated protein kinase 1A antibody;OTTHUMP00000004113 antibody;p90 RSK1 antibody;p90-RSK 1 antibody;p90rsk antibody;p90RSK1 antibody;p90S6K antibody;pp90RSK1 antibody;Ribosomal protein S6 kinase 90kD 1 antibody;Ribosomal protein S6 kinase 90kD polypeptide 1 antibody;Ribosomal protein S6 kinase 90kDa polypeptide 1 antibody;Ribosomal protein S6 kinase alpha 1 antibody;Ribosomal protein S6 kinase alpha-1 antibody;Ribosomal protein S6 kinase polypeptide 1 antibody;Ribosomal S6 kinase 1 antibody;RPS6K1 alpha antibody;rps6ka antibody;Rps6ka1 antibody;RSK 1 antibody;RSK 1 p90 antibody;RSK antibody;RSK-1 antibody;RSK1 antibody;S6K alpha 1 antibody;S6K-alpha-1 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

POST-TRANSLATIONAL MODIFICATION

Activated by phosphorylation at Ser-221 by PDPK1. Autophosphorylated on Ser-380, as part of the activation process. May be phosphorylated at Thr-359 and Ser-363 by MAPK1/ERK2 and MAPK3/ERK1.; N-terminal myristoylation results in an activated kinase in the absence of added growth factors.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. The family of ribosomal S6 kinases (Rsks), designated Rsk-1 (or MAPKAP kinase-1), Rsk-2 and Rsk-3, are intracellular serine/threonine kinases that are important signaling intermediates in response to a broad range of ligand activated receptor tyrosine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.