OGG1 Rabbit Polyclonal Antibody (R1512-5)
Catalog# R1512-5
Rabbit Polyclonal to OGG1
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WB
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IHC-P
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Human
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Mouse
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Rat
Lane 1: Jurkat cell lysate
Lane 2: F9 cell lysate
Lysates/proteins at 20 µg/Lane.
Predicted band size: 39 kDa
Observed band size: 35 kDa
Exposure time: 1 minute; ECL: K1801;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (R1512-5) at 1/2,000 dilution was used in 5% NFDM/TBST at 4℃ overnight. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1/50,000 dilution was used for 1 hour at room temperature.
Specifications
Product Type
Rabbit polyclonal primary
Product Name
OGG1 Rabbit Polyclonal Antibody (R1512-5)
Immunogen
Synthetic peptide within human ogg1 aa 269-345 / 345.
Host
Rabbit
Positive Control
Jurkat cell lysate, F9 cell lysate, mouse skeletal muscle tissue, mouse liver tissue, rat liver tissue, human liver tissue, human liver cancer tissue, human kidney tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:2,000
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IHC-P
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1:200-1:1,000
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 39 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
OGG1
SYNONYMS
8 hydroxyguanine DNA glycosylase antibody;8 oxoguanine DNA glycosylase 1 antibody;8 oxoguanine DNA glycosylase antibody;AP lyase antibody;DNA (apurinic or apyrimidinic site) lyase antibody;DNA apurinic or apyrimidinic site lyase antibody;DNA lyase antibody;DNA-(apurinic or apyrimidinic site) lyase antibody;HMMH antibody;HOGG 1 antibody;HOGG1 antibody;MMH antibody;MUTM antibody;N glycosylase antibody;Ogg 1 antibody;Ogg1 antibody;OGG1_HUMAN antibody;OGH 1 antibody;OGH1 antibody
SEQUENCE SIMILARITIES
Belongs to the type-1 OGG1 family.
TISSUE SPECIFICITY
Ubiquitous.
SUBCELLULAR LOCATION
Mitochondrion, Nucleus.
FUNCTION
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. Defects in OGG1 may be a cause of renal cell carcinoma (RCC). It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.
CITATIONS
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Luan, Z. L., Ming, W. H., Sun, X. W., Zhang, C., Zhou, Y., Zheng, F., Yang, Y. L., Guan, Y. F., & Zhang, X. Y.
A naturally occurring FXR agonist, alisol B 23-acetate, protects against renal ischemia-reperfusion injury
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Mouse
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Citation
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