MTERFD1 Mouse Monoclonal Antibody [A8-A10] (EM1701-29)

UNIPROT #

Q96E29

PROTEIN NAME

MTERFD1

SYNONYMS

CGI 12 antibody;mitochondrial antibody;Mitochondrial transcription termination factor 3 antibody;MTER1_HUMAN antibody;MTERF domain containing 1 antibody;mTERF domain containing protein 1 mitochondrial antibody;mTERF domain-containing protein 1 antibody;mTERF3 antibody;Mterfd1 antibody;Transcription termination factor 3, mitochondrial antibody

SEQUENCE SIMILARITIES

Belongs to the mTERF family.

TISSUE SPECIFICITY

Highly expressed in heart, liver, kidney and testis. Detected at lower levels in brain, spleen and lung.

SUBCELLULAR LOCATION

Mitochondrion.

FUNCTION

MTERFD1 belongs to the MTERF family which consists of four members including MTERF1, MTERF2, MTERF3 and MTERF4. Previous research showed that MTERFD1 is a mitochondrial protein that interacts with the mitochondrial DNA promoter region and decreases transcription initiation in mammalian mitochondria. This negative regulation is likely important for fine-tuning mitochondria transcription in response to physiological demands. Human mitochondrial transcription termination factor domain 1 (MTERFD1) was mutated in many types of cancer. In vivo and in vitro data indicated that MTERFD1 gene possesses oncogenic properties.