Western blot analysis of MTERFD1 on different lysates using anti-MTERFD1 antibody at 1/1,000 dilution.
Lane 1: Hela cell lysates
Lane 2: Mouse kidney tissue lysates
Lane 3: K562 cell lysates
Highly expressed in heart, liver, kidney and testis. Detected at lower levels in brain, spleen and lung.
MTERFD1 belongs to the MTERF family which consists of four members including MTERF1, MTERF2, MTERF3 and MTERF4. Previous research showed that MTERFD1 is a mitochondrial protein that interacts with the mitochondrial DNA promoter region and decreases transcription initiation in mammalian mitochondria. This negative regulation is likely important for fine-tuning mitochondria transcription in response to physiological demands. Human mitochondrial transcription termination factor domain 1 (MTERFD1) was mutated in many types of cancer. In vivo and in vitro data indicated that MTERFD1 gene possesses oncogenic properties.
Just like the interactions between antigens and antibodies, the higher the affinity between you and us the better.