Positive control:
Lane 1: HL-60 cell lysate
Lane 2: A549 cell lysate
Lane 3: Siha cell lysate
Applications
-
WB
REACTIVITY
-
Human
-
Mouse
-
Rat
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
mSin3A Rabbit Polyclonal Antibody (ER2001-38)
Immunogen
Synthetic peptide within human msin3a aa 1-50.
Host
Rabbit
Positive Control
HL-60 cell lysate, A549 cell lysate, Siha cell lysate.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4Á¾ after thawing. Aliquot store at -20Á¾. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Peptide affinity purified.
MOLECULAR WEIGHT
145 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:500-1:1,000
TARGET
UNIPROT #
PROTEIN NAME
mSin3A
SYNONYMS
AW553200 antibody; DKFZP434K2235 antibody; FLJ90319 antibody; Histone deacetylase complex subunit Sin 3a antibody; Histone deacetylase complex subunit Sin3a antibody; KIAA0700 antibody; Kiaa4126 antibody; mKIAA4126 antibody; Paired amphipathic helix protein Sin 3a antibody; Paired amphipathic helix protein Sin3a antibody; Sin 3a antibody; SIN3 homolog A antibody; SIN3 homolog A transcription regulator (yeast) antibody; SIN3 homolog A transcription regulator antibody; SIN3 transcription regulator homolog A antibody; Sin3a antibody; SIN3A protein antibody; SIN3A_HUMAN antibody; Transcriptional co repressor Sin 3A antibody; Transcriptional co repressor Sin3A antibody; Transcriptional corepressor Sin3a antibody; Transcriptional regulator SIN3A antibody
SUBCELLULAR LOCATION
Nucleus.
FUNCTION
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity).