Recombinant Rabbit monoclonal primary
Interferon gamma Recombinant Rabbit Monoclonal Antibody [JM10-10] (ET1703-17)
Human liver tissue, human liver carcinoma tissue, mouse liver tissue, Jurkat.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
IFG antibody; IFI antibody; IFN gamma antibody; IFN, immune antibody; IFN-gamma antibody; IFNG antibody; IFNG_HUMAN antibody; Immune interferon antibody; Interferon gamma antibody
Belongs to the type II (or gamma) interferon family.
Released primarily from activated T lymphocytes.
Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
Interferon (IFN)-γ is an antiviral and antiparasitic agent produced by CD4+/CD8+ lymphocytes and natural killer cells that undergo activation by antigens, mitogens or alloantigens. IFN-γ production modulates T cell growth and differentiation and inhibits the growth of B cells. Synthesis of IFN-γ is inducible by IL-2, FGF and EGF. The active form of IFN-γ is a homodimer with each subunit containing six helices. The dimeric structure of human IFN-γ is stabilized by non-covalent interactions through the interface of the helices. IFN-γ translated precursor is 166 amino acids, including the 23 amino acid secretory sequence. Multiple forms exist due to variable glycosylation and under non-denaturing conditions due to dimers and tetramers.