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Human Osteoprotegerin/TNFRSF11B enzyme-linked immunoassay kit(EH0070)

Price: Regular price $499.00

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Catalog# EH0070

Assay type Sandwich ELISA

Range 6.86~5000 pg/ml

Sensitivity 0.37 pg/ml (50 μl)；2.53 pg/ml (10 μl)

Reacts with

  • Human

PERFORMANCE CHARACTERISTICS

Sensitivity

0.37 pg/ml (50 μl)；2.53 pg/ml (10 μl)

Range

6.86~5000 pg/ml

Recovery

The spike recovery was evaluated by spiking 3 levels of human Osteoprotegerin into health human serum sample. The un-spiked serum was used as blank in this experiment. The recovery ranged from 65% to 98% with an overall mean recovery of 95%.

Specifications

Product Type

ELISA Kit

Product Name

Human Osteoprotegerin/TNFRSF11B enzyme-linked immunoassay kit(EH0070)

Detection method

Colorimetric

Sample type

Serum

Assay type

Sandwich ELISA

Category

PROPERTIES

Storage instructions

Store at +4℃

Kits Components

Coated Plate

96 well

Standard

9 vial

Detect Antibody

6 ml/bottle

Streptavidin-HRP

12 ml/bottle

Assay Buffer

12 ml/bottle

Stop Solution

12 ml/bottle

Wash Buffer

50 ml/bottle

Sealer Film

6 pieces

TARGET

UNIPROT #

O00300

PROTEIN NAME

Osteoprotegerin/TNFRSF11B

SYNONYMS

Tumor necrosis factor receptor superfamily member 11B Osteoclastogenesis inhibitory factor Osteoprotegerin TNFRSF11B OCIF OPG

FUNCTION

Osteoprotegerin (OPG), also known as OCIF and TNFRSF11B, is a secreted TNF superfamily receptor that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts, and endothelial cells. OPG functions as a decoy receptor for TRANCE/RANK L and TRAIL. OPG regulates the cell surface expression of TRANCE and its ability to stimulate osteoclastogenesis. Dysregulation of OPG/TRANCE interactions can lead to juvenile Paget’s disease, osteoporosis, bone loss, and vascular calcification.

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