Fusion glycoprotein F0 Rabbit Polyclonal Antibody (ER1803-51)

UNIPROT #

W8CLH7

PROTEIN NAME

Fusion glycoprotein F0

SYNONYMS

Fusion glycoprotein F0 antibody;Fusion glycoprotein F1 antibody;Fusion glycoprotein F2 antibody;Fusion protein (F) antibody;RSV fusion protein antibody

SEQUENCE SIMILARITIES

Belongs to the paramyxoviruses fusion glycoprotein family.

FUNCTION

During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2. Interacts directly with heparan sulfate and may participate in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis.