Positive control:
Lane 1: Human skin tissue lysate
Lane 2: Mouse stomach tissue lysate
Applications
-
WB
-
ICC
-
IHC-P
REACTIVITY
-
Human
-
Mouse
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
delta 1 Catenin/CAS Rabbit Polyclonal Antibody (ER1901-07)
Immunogen
Synthetic peptide within c-terminal human delta 1 catenin/cas
Host
Rabbit
Positive Control
Human skin tissue, mouse stomach tissue, SiHa, human breast cancer tissue, human kidney tissue, mouse testis tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
PURIFICATION
Immunogen affinity purified.
MOLECULAR WEIGHT
108 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:500-1:2000
-
ICC
-
1:50-1:200
-
IHC-P
-
1:50-1:200
TARGET
UNIPROT #
PROTEIN NAME
delta 1 Catenin/CAS
SYNONYMS
Cadherin associated Src substrate antibody;Cadherin-associated Src substrate antibody;CAS antibody;Catenin (cadherin associated protein) delta 1 antibody;Catenin delta 1 antibody;Catenin delta antibody;Catenin delta-1 antibody;CTND1_HUMAN antibody;CTNND 1 antibody;CTNND antibody;CTNND1 antibody;delta 1 Catenin antibody;KIAA0384 antibody;p120 antibody;P120 CAS antibody;p120 catenin antibody;P120 CTN antibody;p120(cas) antibody;p120(ctn) antibody;P120CAS antibody;P120CTN antibody
SEQUENCE SIMILARITIES
Belongs to the beta-catenin family.
TISSUE SPECIFICITY
Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs.
POST-TRANSLATIONAL MODIFICATION
Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ.
SUBCELLULAR LOCATION
Cell membrane, Cytoplasm, Membrane, Nucleus.
FUNCTION
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.