CRM1 Recombinant Rabbit Monoclonal Antibody [JB35-22] (ET7107-27)

UNIPROT #

O14980

PROTEIN NAME

CRM1

SYNONYMS

Chromosome region maintenance 1 protein homolog antibody;CRM 1 antibody;CRM1 homolog antibody;DKFZp686B1823 antibody;emb antibody;Exp 1 antibody;Exp1 antibody;Exportin 1 antibody;Exportin-1 antibody;Exportin1 antibody;XPO 1 antibody;xpo1 antibody;XPO1_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the exportin family.

TISSUE SPECIFICITY

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney.

SUBCELLULAR LOCATION

Nucleus. Cytoplasm.

FUNCTION

Protein transport across the nucleus is a selective, multistep process involving several cytoplasmic factors. Proteins must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Two cytosolic factors centrally involved in the recognition and docking process are the karyopherin alpha1 and karyopherin beta1 subunits. p62 glycoprotein is a nucleoporin that is not only involved in the nuclear import of proteins, but also the export of nascent mRNA strands. NTF2 (nuclear transport factor 2) interacts with nucleoporin p62 as a homodimer composed of two monomers, and may be an obligate component of functional p62. CRM1 has been shown to be an export receptor for leucine-rich proteins that contain the nuclear export signal (NES).