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Disulfiram enhances the antitumor activity of cisplatin by inhibiting the Fanconi anemia repair pathway
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Discovery of Novel 1,2,3,4-Tetrahydrobenzofuro[2,3-c]pyridine Histone Deacetylase Inhibitors for Efficient Treatment of Hepatocellular Carcinoma
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Fangchinoline Inhibits Human Esophageal Cancer by Transactivating ATF4 to Trigger Both Noxa-Dependent Intrinsic and DR5-Dependent Extrinsic Apoptosis
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Exploring the Potential of Thiophene Derivatives as Dual Inhibitors of β-Tubulin and Wnt/β-Catenin Pathways for Gastrointestinal Cancers in Vitro
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Screening of anti-melanoma compounds from Morus alba L.: Sanggenon C promotes melanoma cell apoptosis by disrupting intracellular Ca2+ homeostasis
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hnRNPH1 maintains mitochondrial homeostasis by establishing NRF1/DRP1 retrograde signaling under mitochondrial stress
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A structure-based virtual screening identifies a novel MDM2 antagonist in the activation of the p53 signaling and inhibition of tumor growth
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Dr Xia Liu,Professor Jianchao Wang
Silencing RRM2 inhibits multiple myeloma by targeting the Wnt/β-catenin signaling pathway
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Chloroquine Intervenes Nephrotoxicity of Nilotinib through Deubiquitinase USP13‐Mediated Stabilization of Bcl‐XL
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Evodiamine Inhibits the Progression of Esophageal Aquamous Cell Carcinoma via Modulating PI3K/AKT/mTOR Pathway
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Chitosan-Coated Selenium Nanoparticles Attenuate PRRSV Replication and ROS/JNK-Mediated Apoptosis in vitro
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Metformin overcomes chemoresistance by regulating stemness via KLF4 in oral squamous cell carcinoma
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Crizotinib induces pulmonary toxicity by blocking autophagy flux in alveolar epithelial cells
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Bis-isatin derivatives: design, synthesis, and biological activity evaluation as potent dimeric DJ-1 inhibitors. Acta pharmacologica Sinica, 10.1038/s41401-020-00600-5. Advance online publication.
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The Long Non-Coding RNA NR3C2-8: 1 Promotes p53-Mediated Apoptosis through the miR-129-5p/USP10 Axis in Amyotrophic Lateral Sclerosis
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Alantolactone induces concurrent apoptosis and GSDME-dependent pyroptosis of anaplastic thyroid cancer through ROS mitochondria-dependent caspase pathway
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Bisdemethoxycurcumin alleviates vandetanib-induced cutaneous toxicity in vivo and in vitro through autophagy activation
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Apatinib Inhibits Bladder Cancer through Suppression of the VEGFR2-PI3K-AKT Signaling Pathway as Revealed by Network Pharmacology and in vitro Experimental Verification
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Yan, H., Wu, W., Hu, Y., Li, J., Xu, J., Chen, X., Xu, Z., Yang, X., Yang, B., He, Q., & Luo, P.
Regorafenib inhibits EphA2 phosphorylation and leads to liver damage via the ERK/MDM2/p53 axis
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Synergistic antitumor activity of regorafenib and rosuvastatin in colorectal cancer
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The role of apoptosis, immunogenic cell death, and macrophage polarization in carbon ion radiotherapy for keloids: Targeting the TGF-β1/SMADs signaling pathway
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Decreased HMGB1 expression contributed to cutaneous toxicity caused by lapatinib
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Modulation of epithelial-mesenchymal transition by gemcitabine: Targeting ionizing radiation-induced cellular senescence in lung cancer cell
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Chaetocin exhibits anticancer effects in esophageal squamous cell carcinoma via activation of Hippo pathway
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Loss of CHCHD2 Stability Coordinates with C1QBP/CHCHD2/CHCHD10 Complex Impairment to Mediate PD-Linked Mitochondrial Dysfunction
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N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma
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Hu, J., Cao, J., Jin, R., Zhang, B., Topatana, W., Juengpanich, S., Li, S., Chen, T., Lu, Z., Cai, X., & Chen, M.
Inhibition of AMPK/PFKFB3 mediated glycolysis synergizes with penfluridol to suppress gallbladder cancer growth
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Network-based pharmacology and in vitro validation reveal that galangin induces apoptosis in bladder cancer cells by promoting the p53 signaling pathway
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Elucidation of the anti-colon cancer mechanism of Phellinus baumii polyphenol by an integrative approach of network pharmacology and experimental verification
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Dasatinib causes keratinocyte apoptosis via inhibiting high mobility group Box 1-mediated mitophagy
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Reduced HMGB1 expression contributed to lapatinib-induced cutaneous injury
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Dabrafenib Alleviates Hepatotoxicity Caused by Lenvatinib via Inhibiting the Death Receptor Signaling Pathway
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Phellinus baumii Polyphenol: A Potential Therapeutic Candidate against Lung Cancer Cells
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Erianin Exerts Antineoplastic Effects on Esophageal Squamous Cell Carcinoma Cells by Activating the cGMP-PKG Signaling Pathway