Lane 1: Hela cell lysate
Lane 2: LOVO cell lysate
Recombinant Rabbit monoclonal primary
CD8 alpha Recombinant Rabbit Monoclonal Antibody [SI18-01] (ET1606-31)
Synthetic peptide within human cd8 alpha aa 186-235 / 235.
Hela cell lysate, LOVO cell lysate, Hela, CRC, human spleen tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
alpha polypeptide (p32) antibody; CD8 antibody; CD8 antigen alpha polypeptide antibody; CD8 antigen alpha polypeptide (p32) antibody; CD8a antibody; CD8A antigen antibody; CD8A molecule antibody; CD8A_HUMAN antibody; Leu2 antibody; Leu2 T lymphocyte antigen antibody; Ly3 antibody; LYT3 antibody; MAL antibody; OKT8 T cell antigen antibody; OTTHUMP00000160760 antibody; OTTHUMP00000160764 antibody; OTTHUMP00000203528 antibody; OTTHUMP00000203721 antibody; p32 antibody; T cell antigen Leu2 antibody; T cell co receptor antibody; T-cell surface glycoprotein CD8 alpha chain antibody; T-lymphocyte differentiation antigen T8/Leu-2 antibody; T8 T cell antigen antibody; T8/Leu-2 T-lymphocyte differentiation antigen antibody
CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and dendritic cells expresses CD8A homodimers. Expressed at the cell surface of plasmacytoid dendritic cells upon herpes simplex virus-1 stimulation.
Palmitoylated, but association with CD8B seems to be more important for the enrichment of CD8A in lipid rafts.; O-glycosylated.; Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.
Cell membrane, Secreted.
The T cell receptor (TCR) is a heterodimer composed of either α and β or γ and δ chains. CD3 chains and the CD4 or CD8 (CD8-α and CD8-β) co-receptors are also required for efficient signal transduction through the TCR. The TCR is expressed on T helper and T cytotoxic cells that can be distinguished by their expression of CD4 and CD8 proteins; T helper cells express CD4 proteins and T cytotoxic cells display CD8 proteins. CD8s are cell surface glycoproteins that exist as two chain complex (αα or αβ) receptors that bind class I MHC molecules presented by the antigen-presenting cell (APC). A primary function of CD8 proteins is to facilitate antigen recognition by the TCR and to strengthen the avidity of the TCR-antigen interactions. An additional role for CD8-expressing T cells may be to maintain low levels of HIV expression.
Li, Yi-Ming et al.
Programmed Death Ligand 1 Indicates Pre-Existing Adaptive Immune Response by Tumor-Infiltrating CD8+ T Cells in Non-Small Cell Lung Cancer. | International Journal of Molecular Sciences