CD1a Rabbit Polyclonal Antibody (ER1902-73)

UNIPROT #

P06126

PROTEIN NAME

CD1a

SYNONYMS

CD 1a antibody;CD1 antibody;CD1a antibody;CD1A Antigen antibody;CD1A antigen, a polypeptide antibody;CD1a molecule antibody;CD1A_HUMAN antibody;cluster of differentiation 1 A antibody;cortical thymocyte antigen CD1A antibody;differentiation antigen CD1 alpha 3 antibody;epidermal dendritic cell marker CD1a antibody;FCB 6 antibody;FCB6 antibody;HTA 1 antibody;HTA1 antibody;hTa1 thymocyte antigen antibody;OTTHUMP00000018907 antibody;R 4 antibody;R4 antibody;T 6 antibody;T-cell surface antigen T6/Leu-6 antibody;T-cell surface glycoprotein CD1a antibody;T6 antibody

TISSUE SPECIFICITY

Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.

SUBCELLULAR LOCATION

Cell membrane. Endosome membrane.

FUNCTION

The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. CD1 antigens are associated with β-2-Microglobulin and expressed on cortical thymocytes, Langerhans cells, a B cell subset and some dendritic cells. Specifically, CD1A is a marker for Langerhans cell histiocytosis (LCH) and is found on interdigitating cells. Adaptor-protein complexes and CD1-associated chaperones control CD1 trafficking, and the development and activation of CD1-restricted T cells. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells. The human CD1 genes are all closely linked in a cluster mapping at chromosome 1q23.1.