CD133 Rabbit Polyclonal Antibody (ER1901-63)

UNIPROT #

O43490

PROTEIN NAME

CD133

SYNONYMS

AC133 antibody;Antigen AC133 antibody;CD133 antibody;CORD12 antibody;Hematopoietic stem cell antigen antibody;hProminin antibody;MCDR2 antibody;MSTP061 antibody;OTTHUMP00000217744 antibody;OTTHUMP00000217745 antibody;OTTHUMP00000217746 antibody;PROM1 antibody;PROM1_HUMAN antibody;Prominin I antibody;Prominin like 1 antibody;Prominin like protein 1 precursor antibody;Prominin mouse like 1 antibody;Prominin-1 antibody;Prominin-like protein 1 antibody;Prominin1 antibody;PROML1 antibody;RP41 antibody;STGD4 antibody

SEQUENCE SIMILARITIES

Belongs to the prominin family.

TISSUE SPECIFICITY

Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, skeletal muscle, kidney, and heart as well as adult pancreas, kidney, liver, lung, and placenta. Isoform 2 is highly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells (at protein level). Expressed in adult retina by rod and cone photoreceptor cells (at protein level).

POST-TRANSLATIONAL MODIFICATION

Isoform 1 and isoform 2 are glycosylated.; Acetylation at Lys-225, Lys-257 and Lys-264 by NAT8 and NAT8B may control PROM1 protein expression and its function in cell apoptosis.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

CD133 antigen, also known as prominin-1, is a glycoprotein that in humans is encoded by the PROM1 gene. It is a member of pentaspan transmembrane glycoproteins, which specifically localize to cellular protrusions. When embedded in the cell membrane, the membrane topology of prominin-1 is such that the N-terminus extends into the extracellular space and the C-terminus resides in the intracellular compartment. The protein consists of five transmembrane segments, with the first and second segments and the third and fourth segments connected by intracellular loops while the second and third as well as fourth and fifth transmembrane segments are connected by extracellular loops. While the precise function of CD133 remains unknown, it has been proposed that it acts as an organizer of cell membrane topology. CD133 is expressed in hematopoietic stem cells, endothelial progenitor cells, glioblastoma, neuronal and glial stem cells, various pediatric brain tumors, as well as adult kidney, mammary glands, trachea, salivary glands, uterus, placenta, digestive tract, testes, and some other cell types.