UNIPROT #

Q03135

PROTEIN NAME

Caveolin-1

SYNONYMS

BSCL3 antibody;CAV antibody;CAV1 antibody;CAV1_HUMAN antibody;caveolae protein, 22 kD antibody;caveolin 1 alpha isoform antibody;caveolin 1 beta isoform antibody;Caveolin 1 caveolae protein 22kDa antibody;Caveolin-1 antibody;Caveolin1 antibody;cell growth-inhibiting protein 32 antibody;CGL3 antibody;LCCNS antibody;MSTP085 antibody;OTTHUMP00000025031 antibody;PPH3 antibody;VIP 21 antibody;VIP21 antibody

SEQUENCE SIMILARITIES

Belongs to the caveolin family.

TISSUE SPECIFICITY

Adipose tissue, lung, heart, skeletal muscle, stomach, small bowel, kidney, spleen and testis (at protein level).

POST-TRANSLATIONAL MODIFICATION

The N-terminus of both isoforms are blocked.; Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.; Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation.

SUBCELLULAR LOCATION

Golgi apparatus membrane, etc

FUNCTION

Caveolin, an integral membrane protein, is a principal component of caveolae membranes in vivo. Two isoforms of caveolin have been identified: a slower migrating 24-kDa species (-isoform) and a faster migrating 21-kDa species (-isoform). Caveolins interact with multiple signaling molecules, such as the G-protein alpha subunit, tyrosine kinase receptors, PKCs, Src family tyrosine kinases and eNOS. Caveolin-1 has been implicated in the pathogenesis of mammary epithelial cell hyperplasia.