Carbonic anhydrase 2 Mouse Monoclonal Antibody [11A1] (EM1801-08)

UNIPROT #

P00918

PROTEIN NAME

Carbonic anhydrase 2

SYNONYMS

CA 2 antibody;CA II antibody;CA-II antibody;Ca2 antibody;CAC antibody;CAH2_HUMAN antibody;CAII antibody;Car 2 antibody;Car2 antibody;Carbonate dehydratase II antibody;Carbonic anhydrase 2 antibody;Carbonic anhydrase B antibody;Carbonic anhydrase C antibody;Carbonic anhydrase C, formerly antibody;Carbonic anhydrase II antibody;Carbonic dehydratase antibody;epididymis luminal protein 76 antibody;Epididymis secretory protein Li 282 antibody;HEL-76 antibody;HEL-S-282 antibody

SEQUENCE SIMILARITIES

Belongs to the alpha-carbonic anhydrase family.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Carbonic anhydrases (CAs) are members of a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. CAs are involved in a variety of biological processes including respiration, calcification, acid-base balance and bone resorption, as well as the formation of aqueous humor, cerebrospinal fluid, saliva and gastric juice. They show extensive diversity in distribution and in their subcellular localization. The human CA2 gene, which maps to chromosome 8q21, encodes CA II, a cytoplasmic protein that has the highest turnover rate and widest tissue distribution of any known human CA isozyme. The human CA4 gene, which maps to chromosome 17q23, encodes CA IV, a membrane-anchored isozyme that is expressed on the luminal surfaces of pulmonary capillaries and proximal renal tubules. The human CA9, CA12 and CA14 genes, which map to chromosomes 9p13, 15q22 and 1q21, respectively, encode transmembrane proteins that have unique patterns of tissue-specific expression.