Applications
-
WB
-
FC
-
IP
REACTIVITY
-
Human
-
Mouse
SPECIFICATIONS
Product Type
Recombinant Rabbit monoclonal primary
Product Name
BDKRB2 Recombinant Rabbit Monoclonal Antibody [JU39-04] (ET7106-74)
Immunogen
Recombinant protein
Host
Rabbit
Positive Control
MCF-7, SH-SY5Y.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
JU39-04
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Protein A purified.
MOLECULAR WEIGHT
80 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:500-1:1,000
-
FC
-
1:50-1:100
-
IP
-
1:10-1:50
TARGET
UNIPROT #
PROTEIN NAME
BDKRB2
SYNONYMS
B2 antibody; B2 bradykinin receptor antibody; B2BKR antibody; B2BRA antibody; B2R antibody; BDKR B2 antibody; BDKRB 2 antibody; BDKRB2 antibody; BK 2 antibody; BK 2 receptor antibody; BK R2 antibody; BK-2 receptor antibody; BK2 antibody; BK2 receptor antibody; BK2R antibody; BKR 2 antibody; BKR2 antibody; BKRB2_HUMAN antibody; BR B2 antibody; Bradykinin receptor B2 antibody; Bradykinin receptor beta 2 antibody; BRB 2 antibody; BRB2 antibody; DKFZp686O088 antibody; Kinin B2 antibody
SEQUENCE SIMILARITIES
Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.
TISSUE SPECIFICITY
Ubiquitous. Widespread in normal smooth muscle tissue and neurons.
SUBCELLULAR LOCATION
Cell membrane.
FUNCTION
Kinins are important biologically active peptides that mediate cardiovascular homeostasis, inflammation and nociception. Bradykinin, the major effector peptide of the kallikrein-kinin system, is regulated by angiotensin-converting enzyme (ACE), which degrades the peptide. Bradykinin normally exerts its effects through the activation of two seven transmembrane G-protein coupled receptors, named B1 and B2. The B2 receptor is constitutively expressed and preferentially binds full length bradykinin. Deletion of the B2 receptor leads to salt-sensitive hypertension and altered nociception in mice. The B1 receptor binds to derivatives of bradykinin and kallidin, which are produced by carboxypeptidase action to generate the products des-Arg9-bradykinin and des-Arg10-kallidin, respectively. The expression of the B1 receptor is inducible by inflammatory mediators, such as bacterial lipopolysaccharide (LPS) and cytokines. The B1 and B2 receptors represent potential therapeutic targets for treatment of inflammatory disorders and cardiovascular diseases.