TdT Rabbit Polyclonal Antibody

Function

Terminal deoxynucleotidyltransferase (TdT) is a DNA polymerase expressed in immature lymphocytes of the thymus and bone marrow, as well as certain leukemic cells. The nuclear enzyme TdT plays a critical role in generating immune receptor diversity. During rearrangement of Ig and TCR V region genes, TdT catalyzes the addition of N nucleotides without a DNA template to V-D and D-J junctions in both Ig and TCR as well as the V-J junctions in the TCR (1–3). During the fetal and newborn period, TdT activity is absent, resulting in an N region-deficient Ag receptor repertoire significantly lacking in the diversity observed in the junctional regions of Igs and TCRs of adult animals

Background References

1. Yamashita N et al. Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65. Genes Cells 6:641-652 (2001).

2. Yang B et al. Mutational analysis of residues in the nucleotide binding domain of human terminal deoxynucleotidyl transferase. J Biol Chem 269:11859-11868 (1994).

3. Peterson R.C et al. Molecular cloning of human terminal deoxynucleotidyltransferase. Proc Natl Acad Sci USA 81:4363-4367 (1984).

Sequence Similarity

Belongs to the DNA polymerase type-X family.

Subcellular Location

Cell nucleus

UNIPROT

SwissProt: P04053 Human

Synonyms

Deoxynucleotidyltransferase terminal antibody

DNA nucleotidylexotransferase antibody

DNTT antibody

Nucleosidetriphosphate DNA deoxynucleotidylexotransferase antibody

TDT antibody

TDT_HUMAN antibody

Terminal addition enzyme antibody

Terminal deoxynucleotidyltransferase antibody

Terminal deoxyribonucleotidyltransferase antibody

Terminal transferase antibody