TMEM119 Rabbit Polyclonal Antibody
Catalog# ER2001-37
TMEM119 Rabbit Polyclonal Antibody
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WB
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Human
-
unconjugated
Overview
Product Name
TMEM119 Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
Synthetic peptide within human Transmembrane protein 119 aa 120-170.
Species Reactivity
Human
Validated Applications
WB
Molecular Weight
Predicted band size: 29 kDa
Positive Control
SHSY5Y cell lysates.
Conjugation
unconjugated
RRID
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Immunogen affinity purified.
Application Dilution
-
WB
-
1:500-1:1,000
Target
Function
Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts . May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Upregulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity).
Background References
1. Kanamoto T. et. al. Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation. BMC Dev. Biol. 9:70-70(2009).
Subcellular Location
Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane.
UNIPROT
Synonyms
OBIF antibody
Osteoblast induction factor antibody
PSEC0199 antibody
Transmembrane protein 119 antibody
UNQ731/PRO1415 antibody
Images
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Western blot analysis of TMEM119 on SHSY5Y cell lysate. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (ER2001-37, 1/500) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:5,000 dilution was used for 1 hour at room temperature.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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