MYH7B Recombinant Rabbit Monoclonal Antibody [JE54-44]

Function

Myosin-7B also known as myosin, heavy chain 7B is a protein that in humans is encoded by the MYH7B gene.MYH7B is a slow-twitch myosin.The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined.

Background References

1. Peter AK. et. al. Expression of Normally Repressed Myosin Heavy Chain 7b in the Mammalian Heart Induces Dilated Cardiomyopathy. J Am Heart Assoc. 2019 Aug.

2. Chen P. et. al. MYH7B variants cause hypertrophic cardiomyopathy by activating the CaMK-signaling pathway. Sci China Life Sci. 2020 Mar.

Sequence Similarity

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

Tissue Specificity

Expressed in heart, skeletal muscle, testis, and all specific brain regions examined. Slightly lower expression was detected in ovary and kidney, and intermediate expression was detected in lung, pancreas, spleen and liver.

Subcellular Location

Membrane.

UNIPROT

SwissProt: A7E2Y1 Human

SwissProt: A2AQP0 Mouse

Entrez Gene: 311570 Rat

Synonyms

Antigen MLAA-21 antibody

cardiac muscle beta isoform antibody

Myh7b antibody

MYH7B_HUMAN antibody

Myosin cardiac muscle beta chain antibody

Myosin heavy chain 7B antibody

Myosin-7B antibody

Slow A MYH14 antibody