FNTB Recombinant Rabbit Monoclonal Antibody [SC06-44]

Function

Mammalian protein farnesyl transferases are heterodimeric proteins containing two nonidentical α and β subunits that attach farnesyl residues to a cysteine at the fourth position from the COOH terminus of several proteins, including nuclear lamins and p21Ras proteins. The natural substrates contain the Cys-A-A-Xaa recognition sequence, where the A residues are aliphatic and Xaa represents methionine, serine, glutamine or cysteine. The purified farnesyl transferase is an a-b heterodimer. The β subunit, which is known as FTβ, CAAX farnesyltransferase subunit β, or Ras proteins prenyltransferase subunit β, is a 437 amino acid protein that contains five PFTB repeats and binds the peptide substrate. The α subunit is suspected to participate in formation of a stable complex with the substrate farnesyl pyrophosphate.

Background References

1. Villalobos, X. et al. 2014. Stability and immunogenicity properties of the gene-silencing polypurine reverse Hoogsteen hairpins. Molecular pharmaceutics. 11: 254-64.

2. Yang, G. et al. 2013. RAS promotes tumorigenesis through genomic instability induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinesis. Int. J. Cancer. 133: 275-285.

Sequence Similarity

Belongs to the protein prenyltransferase subunit beta family.

Subcellular Location

Cytoplasm.

UNIPROT

SwissProt: P49356 Human

SwissProt: Q02293 Rat

Synonyms