EB3 Recombinant Rabbit Monoclonal Antibody [JU38-30]

Function

EB1 (MAPRE2, microtubule-associated protein, RP/EB family, member 2, EB2, RP1) may influence tumorigenesis of colorectal cancers and proliferative control of normal cells. EB1 may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR. Colorectal cancer is caused by the pathologic transformation of normal colonic epithelium to an adenomatous polyp, which can become an invasive cancer. APC (adenomatous polyposis coli) is a tumor suppressor gene, the mutation of which is one of the earliest events in colorectal carcinogenesis. A majority of the mutations result in the loss of the carboxy terminus of APC. EB1 has been shown to bind to the carboxy terminal region of APC, which implicates EB1 in APC suppression of colonic cancer. EB1 overexpression may play a role in the development of human esophageal squamous cell carcinoma (ESCC) by affecting APC function and activating the beta-catenin/TCF pathway. EB3 is related to EB1 and likewise associates with the microtubule cytoskeleton. EB3 is expressed predominantly in the central nervous system and preferentially associates with APCL.

Background References

1. Yang C et al. EB1 and EB3 regulate microtubule minus end organization and Golgi morphology. J Cell Biol 216:3179-3198 (2017).

2. Komarova Y et al. Mammalian end binding proteins control persistent microtubule growth. J Cell Biol 184:691-706 (2009).

Sequence Similarity

Belongs to the MAPRE family.

Tissue Specificity

Predominantly expressed in brain and muscle.

Subcellular Location

Cytoplasm, cytoskeleton.

UNIPROT

SwissProt: Q9UPY8 Human

SwissProt: Q6PER3 Mouse

SwissProt: Q5XIT1 Rat

Synonyms