RBPMS Polyclonal Antibody

Function

This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA.

Background References

1. Teplova M et al. Structural basis underlying CAC RNA recognition by the RRM domain of dimeric RNA-binding protein RBPMS. Q. Rev. Biophys. 2015:1-11 (2015).

2. Sun Y et al. Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS. Nucleic Acids Res. 34:6314-6326 (2006).

Tissue Specificity

Ubiquitously expressed, at various levels depending on the isoform and the tissue.

Subcellular Location

Cytoplasm. Nucleus.

UNIPROT

SwissProt: Q93062 Human

SwissProt: Q9WVB0 Mouse

Synonyms

RNA-binding protein with multiple splicing

Heart and RRM expressed sequence