IGF2R/M6PR Rabbit Polyclonal Antibody (R1510-3)

UNIPROT #

P11717

PROTEIN NAME

IGF2R/M6PR

SYNONYMS

300 kDa mannose 6 phosphate receptor antibody;300 kDa mannose 6-phosphate receptor antibody;Cation independent mannose 6 phosphate receptor antibody;Cation-independent mannose-6-phosphate receptor antibody;CD222 antibody;CD222 antigen antibody;CI Man 6 P receptor antibody;CI Man-6-P receptor antibody;CI MPR antibody;CI-M6PR antibody;CI-MPR antibody;CIMPR antibody;IGF 2 receptor antibody;IGF 2R antibody;IGF II receptor antibody;IGF-II receptor antibody;IGF2 receptor antibody;Igf2r antibody;Insulin like growth factor 2 receptor antibody;Insulin like growth factor II receptor antibody;Insulin-like growth factor 2 receptor antibody;Insulin-like growth factor II receptor antibody;M6P R antibody;M6P/IGF2 receptor antibody;M6P/IGF2R antibody;M6PR antibody;mannose 6 phosphate receptor antibody;mannose 6 phosphate receptor, cation independent antibody;MPR 300 antibody;MPR300 antibody;MPRI antibody;MPRI_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the MRL1/IGF2R family.

SUBCELLULAR LOCATION

Golgi apparatus membrane, Endosome membrane.

FUNCTION

The mannose 6-phosphate/insulin-like growth factor II receptor, IGF-IIR (also designated M6P/IGF2R), is a ubiquitously expressed integral glycoprotein. By binding glycoproteins through two of its extracytoplasmic domains, IGF-IIR mediates the activation of TGF∫1 (a growth inhibitor), the degradation of IGF-II and the transport of lysosomal enzymes. Subsequently, IGF-IIR can form oligomeric complexes, which increase the affinity of IGF-IIR for lysosomal enzymes. Unlike IGF-IR, IGF-IIR does not potentiate the signaling of IGF-I or IGF-II, which have mitogenic, cell survival and insulin-like effects. Therefore, IGF-IIR is characterized as a tumor suppressor. Furthermore, the IGF-IIR gene is located on chromosome 6q26, which is commonly mutated or deleted in several human cancers.