MAL Rabbit Polyclonal Antibody
Catalog# R1311-6
MAL Rabbit Polyclonal Antibody
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IHC-P
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WB
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Human
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Mouse
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Rat
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unconjugated
Overview
Product Name
MAL Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
Synthetic peptide within mouse MAL aa 103-146.
Species Reactivity
Human, Mouse, Rat
Validated Applications
IHC-P, WB
Target Molecular Weight
Predicted band size: 17 kDa
Positive Control
K562, mouse stomach
Conjugation
unconjugated
RRID
Product Features
Form
Liquid
Concentration
1 mg/mL.(The concentration of this product may be batch-dependent)
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Immunogen affinity purified.
Application Dilution
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IHC-P
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1:100
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WB
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1:500
Target
Function
Myelin and lymphocyte protein is a protein that in humans is encoded by the MAL gene.The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3.
Background References
1. Llorente A, de Marco MC, Alonso MA (2005). "Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line". J. Cell. Sci. 117 (Pt 22): 5343–51.
2. Dukhovny A, Goldstein Magal L, Hirschberg K (2006). "The MAL proteolipid restricts detergent-mediated membrane pore expansion and percolation". Mol. Membr. Biol. 23 (3): 245–57.
3. Mimori K, Nishida K, Nakamura Y et al. (2007). "Loss of MAL expression in precancerous lesions of the esophagus". Ann. Surg. Oncol. 14 (5): 1670–7.
Sequence Similarity
Belongs to the MAL family.
Post-translational Modification
Lipoprotein.
Subcellular Location
Membrane
Synonyms
Mal antibody
MAL protein gene antibody
Mal T-cell differentiation protein antibody
MAL_HUMAN antibody
MALGENE antibody
MPV17 antibody
Myelin and lymphocyte protein antibody
T-cell differentiation protein MAL antibody
T-lymphocyte maturation-associated protein antibody
VIP17 antibody
Images
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Immunohistochemical analysis of paraffin-embedded mouse stomach tissue using anti- MAL rabbit polyclonal antibody.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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