CD79a Rabbit Polyclonal Antibody

Function

The mb-1 gene codes for a phosphoprotein, designated CD79a, that, together with the related CD79b protein, forms a dimer associated with membrane-bound immunoglobulin in B-cells. The CD79a/CD79b dimer is closely associated with the B-cell antigen receptor, in a similar manner to the association of CD3 with the T-cell receptor, and enables the cell to respond to the presence of antigens on its surface. The CD79a protein is present on the surface of B-cells throughout their life cycle, and is absent on all other healthy cells, making it a highly reliable marker for B-cells in immunohistochemistry

Background References

1. Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas. Naylor TL, et al. Cancer Res, 2011 Apr 1.

2. BOB.1, CD79a and cyclin E are the most appropriate markers to discriminate classical Hodgkin\'s lymphoma from primary mediastinal large B-cell lymphoma. Hoeller S, et al. Histopathology, 2010 Jan.

Tissue Specificity

B-cells.

Post-translational Modification

Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases, including LYN, is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation.; Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation.

Subcellular Location

Cell membrane

UNIPROT

SwissProt: P11911 Mouse

Synonyms