SUZ12 Rabbit Polyclonal Antibody
Catalog# R1110-2
SUZ12 Rabbit Polyclonal Antibody
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WB
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Human
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Mouse
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unconjugated
Overview
Product Name
SUZ12 Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
Synthetic peptide within Human SUZ12 aa 481-520 / 739.
Species Reactivity
Human, Mouse
Validated Applications
WB
Target Molecular Weight
Predicted band size: 83kDa
Positive Control
MCF-7, Hela, SW480, 293T, N2A F9
Conjugation
unconjugated
RRID
Product Features
Form
Liquid
Concentration
1 mg/mL.(The concentration of this product may be batch-dependent)
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Immunogen affinity purified.
Application Dilution
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WB
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1:2,000-1:5,000
Target
Function
Polycomb protein SUZ12 is a nuclear protein belonging to the VEFS (VRN2-EMF2-FIS2-SUZ12) family. It is overexpressed in breast and colon cancer, expressed at low levels in quiescent cells. Expression rises at the G1/S phase transition. A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer.
Background References
1. de la Cruz CC, Kirmizis A, Simon MD, Isono K, Koseki H, Panning B. The polycomb group protein SUZ12 regulates histone H3 lysine 9 methylation and HP1 alpha distribution. Chromosome Res 2007; 15: 299-314
2. Pasini D, Bracken AP, Hansen JB, Capillo M, Helin K. The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol 2007; 27: 3769-3779
Sequence Similarity
Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.
Tissue Specificity
Overexpressed in breast and colon cancer.
Post-translational Modification
Sumoylated, probably by PIAS2.
Subcellular Location
Nucleus
Synonyms
ChET 9 protein antibody
CHET9 antibody
Chromatin precipitated E2F target 9 protein antibody
JJAZ1 antibody
Joined to JAZF1 protein antibody
KIAA0160 antibody
Polycomb protein SUZ12 antibody
Suppressor of zeste 12 homolog antibody
Suppressor of zeste 12 protein homolog antibody
SUZ12 antibody
ExpandImages
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Western blot analysis on cell lysates using anti-SUZ12 rabbit polyclonal antibody.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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