PODXL Mouse Monoclonal Antibody [D0-E8]

Function

Podocalyxin, a sialoglycoprotein, is thought to be the major constituent of the glycocalyx of podocytes. It is a member of the CD34 family of transmembrane sialomucins. It is involved in the regulation of both adhesion and cell morphology and cancer progression. It functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Podocalyxin acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Sialylated, O-glycosylated glycoforms of podocalyxin expressed by colon carcinoma cells possess L-selectin and E-selectin binding activity, and may be pivotal to the metastatic spread of colon carcinoma cells

Background References

1. "Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with ezrin." Sizemore S., Cicek M., Sizemore N., Ng K.P., Casey G. Cancer Res. 67:6183-6191(2007)

2. "Expression of podocalyxin enhances the adherence, migration, and intercellular communication of cells." Larrucea S., Butta N., Arias-Salgado E.G., Alonso-Martin S., Ayuso M.S., Parrilla R. Exp. Cell Res. 314:2004-2015(2008)

Sequence Similarity

Belongs to the podocalyxin family.

Tissue Specificity

Glomerular epithelium cell (podocyte).

Post-translational Modification

N- and O-linked glycosylated. Sialoglycoprotein (By similarity).

Subcellular Location

Apical cell membrane

UNIPROT

SwissProt: O00592 Human

Synonyms