PTPRB Mouse Monoclonal Antibody [2-A2]

Function

DNA (cytosine-5)-methyltransferase 3-like is an enzyme that in humans is encoded by the DNMT3L Receptor-type tyrosine-protein phosphatase beta is an enzyme that in humans is encoded by the PTPRB gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRB plays an important role in blood vessel remodeling and angiogenesis. It is not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. PTPRB can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. It regulates angiopoietin-TIE2 signaling in endothelial cells.

Background References

1. Nawroth, Roman; Poell Gregor; Ranft Alexander; Kloep Stephan; Samulowitz Ulrike; Fachinger Gregor; Golding Matthew; Shima David T; Deutsch Urban; Vestweber Dietmar (Sep 2002). "VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts". EMBO J. (England) 21 (18): 4885–95.

2. Adamsky, Konstantin; Arnold Katya; Sabanay Helena; Peles Elior (Apr 2003). "Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins". J. Cell. Sci. (England) 116 (Pt 7): 1279–89.

Sequence Similarity

Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

Subcellular Location

Membrane

UNIPROT

SwissProt: P23467 Human

Synonyms