LNP Mouse Monoclonal Antibody [7-3]

Function

Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within three-way ER tubular junction network. May be involved in limb and central nervous system development

Background References

1. Spitz F et al. A global control region defines a chromosomal regulatory landscape containing the HoxD cluster. Cell 113:405-417 (2003).

2. Kmita, M et al. Evolutionary conserved sequences are required for the insulation of the vertebrate HoxD complex in neural cells. Development. 129: 5521–5528 (2002).

Sequence Similarity

Belongs to the lunapark family.

Tissue Specificity

Expressed in neural precursor cells, where it is detected at the growth-cone-like structure and branching sites of neurite-like processes.

Post-translational Modification

Myristoylated; myristoylation is necessary for the endoplasmic reticulum (ER) three-way ER tubular junction formation, but is not required neither for membrane translocation, membrane topology formation, nor for the specific localization to ER membranes.; Phosphorylated. Phosphorylation occurs at Ser-177, Ser-182, Ser-217, Ser-227, Ser-321 and Ser-384 during interphase. Phosphorylation occurs at Ser-114, Ser-153, Ser-194, Thr-211 and Ser-353 during mitosis; these phosphorylations reduce both its homodimerization and the ER three-way tubular junction formation.; Subject to proteasomal degradation following phosphorylation during mitosis.

Subcellular Location

Endoplasmic reticulum.

UNIPROT

SwissProt: Q9C0E8 Human

SwissProt: Q7TQ95 Mouse

SwissProt: A0JN29 Rat

Synonyms

lnp antibody

LNP_HUMAN antibody

Protein lunapark antibody