IL-19 Rabbit Polyclonal Antibody
Catalog# ER1802-1
IL-19 Rabbit Polyclonal Antibody
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IF-Cell
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IHC-P
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Human
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unconjugated
Overview
Product Name
IL-19 Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
Synthetic peptide within mouse IL19 aa 127-176 / 176.
Species Reactivity
Human
Validated Applications
IF-Cell, IHC-P
Target Molecular Weight
Predicted band size: 20 kDa
Positive Control
Hela, HUVEC, SH-SY5Y, human tonsil tissue, human spleen tissue.
Conjugation
unconjugated
RRID
Product Features
Form
Liquid
Concentration
1 mg/mL.(The concentration of this product may be batch-dependent)
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Immunogen affinity purified.
Application Dilution
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IF-Cell
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1:50-1:200
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IHC-P
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1:50-1:100
Target
Function
Interleukin 19 (IL-19) is an immunosuppressive protein that belongs to the IL-10 cytokine subfamily. IL-19 is associated with broad functions across inflammation, cell development, viral responses, and lipid metabolism. As an immunosuppressive cytokine, IL-19 promotes the Th2 (regulatory) T-cell response which supports an anti-inflammatory lymphocyte phenotype, dampens the Th1 T-cell response and inflammatory cytokine secretion (IFNγ), increases IL-10 (anti-inflammatory) expression in peripheral blood mononuclear cells (PBMC), and inhibits the production of immunoglobulin G (IgG) from B cells.
Background References
1. Lee GA et al. IL-19 as a promising theranostic target to reprogram the glioblastoma immunosuppressive microenvironment. J Biomed Sci. 2025 Mar
2. Deng J et al. IL-19 suppresses Hippo signaling via modulating YAP1 phosphorylation in osteoarthritis. Front Immunol. 2025 Oct
Sequence Similarity
Belongs to the IL-10 family.
Subcellular Location
Secreted.
UNIPROT
Synonyms
IL 10C antibody
IL 19 antibody
IL-19 antibody
Il19 antibody
IL19_HUMAN antibody
Interleukin 19 antibody
Interleukin-19 antibody
MDA1 antibody
Melanoma differentiation-associated protein-like protein antibody
NG.1 antibody
ExpandImages
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ICC staining IL19 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
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ICC staining IL19 in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
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ICC staining IL19 in SH-SY5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
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Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-IL19 antibody. Counter stained with hematoxylin.
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Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-IL19 antibody. Counter stained with hematoxylin.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"