GPR132 Rabbit Polyclonal Antibody

Function

G protein coupled receptor 132, also termed G2A, is classified as a member of the proton sensing G protein coupled receptor (GPR) subfamily. Like other members of this subfamily, i.e. GPR4, OGR1 (GPR68), and TDAG8 (GPR65), G2A is a G protein coupled receptor that resides in the cell surface membrane, senses changes in extracellular pH, and can alter cellular function as a consequence of these changes. Subsequently, G2A was suggested to be a receptor for lysophosphatidylcholine (LPC). However, the roles of G2A as a pH-sensor or LPC receptor are disputed. Rather, current studies suggest that it is a receptor for certain metabolites of the polyunsaturated fatty acid, linoleic acid. G2A was initially defined as one of the gene products whose production was stimulated in mouse pre-B lymphocytes (see Immunoglobulin heavy chain) by transfecting the cells with the human oncogene (i.e., cancer causing) BCR-ABL or by treating the cells with DNA damaging agents; its expression in these cells blocked their progression through the cell cycle specifically at the G2-M DNA damage checkpoint. A report working with human neutrophils proposed that G2A was a receptor for a phospholipid, lysophosphatidylcholine (LPC), and a Sphingomyelin, sphingosylphosphorylcholine.

Background References

1. "The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis." Lin P., Ye R.D. J. Biol. Chem. 278:14379-14386(2003)

2. "A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M." Weng Z., Fluckiger A.-C., Nisitani S., Wahl M.I., Le L.Q., Hunter C.A., Fernal A.A., Le Beau M.M., Witte O.N. Proc. Natl. Acad. Sci. U.S.A. 95:12334-12339(1998)

Sequence Similarity

Belongs to the G-protein coupled receptor 1 family.

Tissue Specificity

Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus. Weakly expressed in heart and lung. In atherosclerotic plaques, expression is observed around the lipid core and at the shoulder region.

Subcellular Location

Cell membrane.

UNIPROT

SwissProt: Q9UNW8 Human

SwissProt: Q9Z282 Mouse

Synonyms

G Protein Coupled Receptor G2A antibody

G2 accumulation protein antibody

G2A antibody

GP132_HUMAN antibody

GPR132 antibody

Probable G-protein coupled receptor 132 antibody