Figla Rabbit Polyclonal Antibody

Function

Ovarian folliculogenesis is an intricate process involving interactions between germ and somatic cells in mammalians. FIGLA (folliculogenesis specific basic helix-loop-helix), also known as POF6, BHLHC8 or FIGALPHA, is a 219 amino acid nuclear protein expressed in fetal ovary and germ cells. FIGLA contains one basic helix-loop-helix (bHLH) domain and heterodimerizes with E12, a transcription factor that influences gene expression during B cell maturation. Acting as a germline specific transcription factor and a key player of ovarian folliculogenesis, FIGLA regulates the expression of multiple oocyte-specific genes that are required for fertilization and early embryonic survival. Mutations in the gene encoding FIGLA may be the cause of Premature Ovarian Failure (POF), a genetically heterogenous disorder that leads to hypergonadotropic ovarian failure and infertility. POF is characterized by amenorrhea, hypoestrogenism and elevated serum gonadotropin concentrations. FIGLA inhibits the expression of male germ cell specific genes during oogenesis.

Background References

1. Soyal S.M., et al. FIGalpha, a germ cell-specific transcription factor required for ovarian follicle formation. Development 127:4645-4654(2000).

2. Liang L.-F.,et al. FIGalpha, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes. Development 124:4939-4947(1997).

Tissue Specificity

Expressed only in the oocytes within the ovary and at lower level in the testis. Found in the resting oocytes of the primordial follicle cells, at the periphery of the ovary and in the hilar region. Also detected in growing oocytes, but at lower levels.

Subcellular Location

Cytoplasm

UNIPROT

SwissProt: O55208 Mouse

Synonyms

bHLHc8 antibody

Class C basic helix-loop-helix protein 8 antibody

Factor in the germline alpha antibody

FIGalpha antibody

FIGLA antibody

FIGLA_HUMAN antibody

Folliculogenesis specific basic helix loop helix antibody

Folliculogenesis-specific basic helix-loop-helix protein antibody

POF6 antibody

Transcription factor FIGa antibody