ADAM22 Rabbit Polyclonal Antibody

Function

Disintegrin and metalloproteinase domain-containing protein 22 also known as ADAM22 is an enzyme that in humans is encoded by the ADAM22 gene. ADAM22 is a member of the ADAM (A Disintegrin And Metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. Alternative splicing results in several transcript variants. ADAM22 has been shown to interact with DLG4.

Background References

1. Zhu P. et. al. The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading. Biochem. Biophys. Res. Commun. 301:991-999(2003).

Subcellular Location

Cell membrane, Cell projection, Membrane.

UNIPROT

SwissProt: Q9P0K1 Human

SwissProt: Q9R1V6 Mouse

Synonyms