FEZF2 Rabbit Polyclonal Antibody
Catalog# ER1802-22
FEZF2 Rabbit Polyclonal Antibody
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WB
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Zebrafish
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unconjugated
Overview
Product Name
FEZF2 Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
Recombinant protein within zebrafish FEZF2 aa 251-385 / 438.
Species Reactivity
Zebrafish
Validated Applications
WB
Target Molecular Weight
47 kDa
Positive Control
Zebrafish.
Conjugation
unconjugated
RRID
Reactivity Data
Verified (internally validated)
Reported in literature (not internally validated)
Predicted reactive (based on sequence homology)
Not recommended (failed internal validation)
| WB | IHC-P | |
|---|---|---|
| Zebrafish |
|
|
Product Features
Form
Liquid
Concentration
1 mg/mL.(The concentration of this product may be batch-dependent)
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Immunogen affinity purified.
Application Dilution
-
WB
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1:500-1:1000
Target
Function
ZNF312, also known as Fezf2 or Fez-like, is a zinc finger protein that acts as a transcriptional repressor during the development of corticospinal motor neurons and other subcerebral projection neurons. ZNF312 is expressed by early progenitor cells in the ventricular zone. It regulates the fate choice of subcortical projection neurons in the developing cerebral cortex. This protein is expressed in the developing cortical plate during early embryonic development. During late embryonic development and early postnatal development, ZNF312 expression disappears from the cortical progenitors and becomes restricted to the subplate nad the prospective layer V and VI pyramidal neurons.
Background References
1. Levkowitz G et al. Zinc finger protein too few controls the development of monoaminergic neurons. Nat Neurosci 6:28-33 (2003).
2. Yang Z et al. A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2 and dlx6 expression. Dev Biol 231:138-148 (2001).
Sequence Similarity
Belongs to the krueppel C2H2-type zinc-finger protein family.
Tissue Specificity
No expression seen in DA or 5HT neurons.
Subcellular Location
Nucleus.
UNIPROT
Synonyms
Fez antibody
FEZ family zinc finger protein 2 antibody
FEZF 2 antibody
FEZF2 antibody
FEZL antibody
Forebrain embryonic zinc finger like protein 2 antibody
TOF antibody
ZFP 312 antibody
ZFP312 antibody
Zinc finger FEZL antibody
ExpandImages
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Western blot analysis of FEZF2 on Zebrafish tissue lysates using anti-FEZF2 antibody at 1/500 dilution.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"