DKK1 Rabbit Polyclonal Antibody

Function

Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene. This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the Wnt signaling pathway. Dickkopf WNT signaling pathway inhibitor 1 (Dkk1) is a protein-coding gene that acts from the anterior visceral endoderm. The dickkopf protein encoded by DKK1 is an antagonist of the Wnt/β-catenin signalling pathway that acts by isolating the LRP6 co-receptor so that it cannot aid in activating the WNT signaling pathway. This inhibition plays a key role in heart, head and forelimb development during anterior morphogenesis of the embryo.

Background References

1. Zhang Z et al. DKK1 loss promotes endometrial fibrosis via autophagy and exosome-mediated macrophage-to-myofibroblast transition. J Transl Med. 2024 Jul

2. Zeng P et al. ERK1/2 inhibition reduces vascular calcification by activating miR-126-3p-DKK1/LRP6 pathway. Theranostics. 2021 Jan

Sequence Similarity

Belongs to the dickkopf family.

Tissue Specificity

Placenta.

Subcellular Location

Secreted.

UNIPROT

SwissProt: O94907 Human

SwissProt: O54908 Mouse

Synonyms