IL-6 Mouse Monoclonal Antibody [11-D4] (EM1701-58)

UNIPROT #

P05231

PROTEIN NAME

IL-6

SYNONYMS

Interleukin BSF 2 antibody;B cell differentiation factor antibody;B cell stimulatory factor 2 antibody;B-cell stimulatory factor 2 antibody;BSF 2 antibody;BSF-2 antibody;BSF2 antibody;CDF antibody;CTL differentiation factor antibody;Hepatocyte stimulatory factor antibody;HGF antibody;HSF antibody;Hybridoma growth factor antibody;Hybridoma growth factor Interferon beta-2 antibody;IFN-beta-2 antibody;IFNB2 antibody;IL 6 antibody;IL-6 antibody;IL6 antibody;IL6_HUMAN antibody;Interferon beta 2 antibody;Interferon beta-2 antibody;Interleukin 6 antibody;Interleukin 6 (interferon beta 2) antibody;Interleukin BSF 2 antibody;Interleukin-6 antibody

SEQUENCE SIMILARITIES

Belongs to the IL-6 superfamily.

POST-TRANSLATIONAL MODIFICATION

N- and O-glycosylated.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Interleukin-6, or IL-6, is a multifunctional protein, 212 amino acids in length, that plays critical roles in host defense, immune response and hematopoiesis. IL-6 is constitutively expressed by epidermal Langerhans cells and its expression is induced in stimulated keratinocytes. IL-6, IL-1β and TNFα act as endogenous pyrogens, regulating the fever response to bacterial invasion. The IL-6 receptor is a trimeric complex composed of an IL-6-specific α chain and a homodimer of the gp130 glycoprotein common to the IL-6, IL-11, CNTF, OSM and LIF receptors. Stimulation with IL-6 leads to gp130 homodimerization and the activation of associated kinases JAK1 and JAK2. Once activated, JAK1 and JAK2 phosphorylate Stat3, causing its nuclear translocation and transcription of Stat3-responsive genes. IL-6 has also been shown to activate the Ras/MAP kinase pathway, which regulates NFIL6 transcription.