DNMT3L Mouse Monoclonal Antibody [B0-5]

Function

DNA (cytosine-5)-methyltransferase 3-like is an enzyme that in humans is encoded by the DNMT3L gene. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1.

Background References

1. "DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA." Ooi S.K., Qiu C., Bernstein E., Li K., Jia D., Yang Z., Erdjument-Bromage H., Tempst P., Lin S.-P., Allis C.D., Cheng X., Bestor T.H. Nature 448:714-717(2007)

2. "Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation." Jia D., Jurkowska R.Z., Zhang X., Jeltsch A., Cheng X. Nature 449:248-251(2007)

Tissue Specificity

Expressed at low levels in several tissues including testis, ovary, and thymus.

Subcellular Location

Nucleus

UNIPROT

SwissProt: Q9UJW3 Human

Synonyms

Cytosine 5 methyltransferase 3 like protein antibody

DNA (cytosine 5 ) methyltransferase 3 like antibody

DNA (cytosine-5)-methyltransferase 3-like antibody

DNA cytosine 5 methyltransferase 3 like protein antibody

DNA methyltransferase 3 like protein antibody

DNM3L_HUMAN antibody

Dnmt 3L antibody

Dnmt3l antibody

Human cytosine 5 methyltransferase 3 like protein antibody

MGC1090 antibody