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AVPR1A Rabbit Polyclonal Antibody

Usd: 315

Specification

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Catalog# HA500002

AVPR1A Rabbit Polyclonal Antibody

Application

  • WB

Reactivity

  • Human

  • Mouse

Conjugation

  • unconjugated

Overview

Product Name

AVPR1A Rabbit Polyclonal Antibody

Antibody Type

Rabbit Polyclonal Antibody

Immunogen

Synthetic peptide within N-terminal human AVPR1A.

Species Reactivity

Human, Mouse

Validated Applications

WB

Molecular Weight

Predicted band size: 47 kDa

Positive Control

A549 cell lysate, HL-60 cell lysate, C2C12 cell lysate, mouse liver tissue lysate.

Conjugation

unconjugated

RRID

AB_3071102

Product Features

Form

Liquid

Concentration

Storage Instructions

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Isotype

IgG

Purification Method

Immunogen affinity purified.

Application Dilution

  • WB

  • 1:500-1:1,000

Target

Function

Human AVPR1A cDNA is 1472 bp long and encodes a 418 amino-acid long polypeptide which shares 72%, 36%, 37%, and 45% sequence identity with rat Avpr1a, human AVPR2, rat Avpr2, and human oxytocin receptor (OXTR), respectively. AVPR1A is a G-protein coupled receptor (GPCR) with 7 transmembrane domains that couples to Gaq/11 GTP binding proteins, which along with Gbl, activate phospholipase C activity.[5][6] Clinically, the V1A receptor is related to vasoconstriction compared to the V1B receptor that is more related to ACTH release or the V2 receptor that is linked to the diuretic function of ADH.

Background References

1. Kim S.J., et al, Transmission disequilibrium testing of arginine vasopressin receptor 1A (AVPR1A) polymorphisms in autism. Mol. Psychiatry 7:503-507(2002).

Subcellular Location

Cell membrane, Membrane.

UNIPROT

SwissProt: P37288 Human

SwissProt: Q8C0J2 Mouse

Synonyms

Antidiuretic hormone receptor 1a antibody

Arginine vasopressin receptor 1A antibody

AVPR 1 antibody

AVPR 1A antibody

AVPR V1a antibody

AVPR1 antibody

AVPR1A antibody

SCCL vasopressin subtype 1a receptor antibody

V1 vascular vasopressin receptor AVPR1A antibody

V1a vasopressin receptor antibody

Expand

Images

  • Western blot analysis of AVPR1A on different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (<a href="/products/HA500002" style="font-weight: bold;text-decoration: underline;">HA500002</a>, 1/500) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (<a href="/products/HA1001" style="font-weight: bold;text-decoration: underline;">HA1001</a>) at 1:5,000 dilution was used for 1 hour at room temperature.<br />Positive control: <br />Lane 1: A549 cell lysate<br />Lane 2: HL-60 cell lysate<br />Lane 3: C2C12 cell lysate<br />Lane 4: Mouse liver tissue lysate

    Western blot analysis of AVPR1A on different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (HA500002, 1/500) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:5,000 dilution was used for 1 hour at room temperature.
    Positive control:
    Lane 1: A549 cell lysate
    Lane 2: HL-60 cell lysate
    Lane 3: C2C12 cell lysate
    Lane 4: Mouse liver tissue lysate

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"