Cadherin EGF LAG seven-pass G-type receptor 2 Rabbit Polyclonal Antibody (0905-6)

UNIPROT #

Q9HCU4

PROTEIN NAME

Cadherin EGF LAG seven-pass G-type receptor 2

SYNONYMS

Cadherin EGF LAG seven pass G type receptor 2 flamingo Drosophila homolog antibody;Cadherin EGF LAG seven-pass G-type receptor 2 antibody;Cadherin family member 10 antibody;CDHF10 antibody;CELR2_HUMAN antibody;Celsr2 antibody;EGF like domain multiple 2 antibody;EGF-like protein 2 antibody;EGFL2 antibody;epidermal growth factor like 2 antibody;Epidermal growth factor-like protein 2 antibody;Flamingo homolog 3 antibody;Flamingo1 antibody;KIAA0279 antibody;MEGF3 antibody;Multiple EGF-like domains protein 3 antibody;Multiple epidermal growth factor-like domains 3 antibody;Multiple epidermal growth factor-like domains protein 3 antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

TISSUE SPECIFICITY

Highest expression in brain and testis.

POST-TRANSLATIONAL MODIFICATION

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

SUBCELLULAR LOCATION

Cell membrane

FUNCTION

Cadherin EGF LAG seven-pass G-type receptor 2 belongs to the G-protein coupled receptor 2 family, highest expressed in brain and testis. The protein encoded by the gene CELSR2 is a member of the flamingo subfamily, part of the cadherin superfamily. It may have an important role in cell/cell signaling during nervous system formation.